ADHD medications
First non-stimulant option
Alternative or adjunct
Adjunct option
Non-stimulant medications
Non-stimulant medications are typically used as second-line treatments in ADHD, and may be considered in a range of clinical situations.
When non-stimulants may be used
Stimulants not suitable
E.g. cardiovascular concerns or substance use history
Side effect limits
When side effects limit the use of stimulant therapy
Combination therapy
Additional symptom control alongside stimulant medication
Medications
Atomoxetine
Strattera®
Works on brain chemicals involved in attention and behaviour. Often used when stimulant medications are not appropriate or not well tolerated.
Guanfacine
Intuniv®
May be used as an alternative to stimulants, or in combination with stimulant therapy to improve overall symptom control.
May also help with
Clonidine
Generic / various brands
Sometimes used alongside stimulant medication or to assist with sleep and residual symptoms. May be considered if other options are not suitable or effective.
General principles
Non-stimulants tend to have a slower onset of action compared to stimulants.
They may take several weeks to reach their full effect — patience during this phase is important.
Choice of medication depends on individual factors, including symptoms, side effects, and medical history.